Genetic research papers on sexual abnormalities

We have known for decades that sexual orientation is partly heritable in men, thanks to studies of families in which some people are straight and some people are gay. Both findings were confirmed in a study of gay and straight brothers in For the first time, individual genes have been identified that may influence how sexual orientation develops in boys and men, both in the womb and during life.

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Sex linked is a trait in which a gene is located on a sex chromosome. In humans, the term generally refers to traits that are influenced by genes on the X chromosome. This is because the X chromosome is large and contains many more genes than the smaller Y chromosome.

Scientists have turned male mice into females by snipping out strands of their DNA in work that could shed light on sexual development disorders which arise in humans. The findings could help explain why people with XY chromosomes who are missing similar strands of DNA can go on to develop female sex organs, the scientists say. Males are typically born with X and Y chromosomes, while females have two Xs. Researchers at the Francis Crick Institute in London showed that they could reverse the sex of male mice by deleting a chunk of DNA called enhancer 13, or Enh13 for short.

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The relationship between biology and sexual orientation is a subject of research. While scientists do not know what determines an individual's sexual orientationthey theorize that it is caused by a complex interplay of genetichormonaland environmental influences. Biological theories for explaining the causes of sexual orientation are favored by scientists.

How do genes influence our sexuality? The question has long been fraught with controversy. An ambitious new study — the largest ever to analyze the genetics of same-sex sexual behavior — found that genetics does play a role, responsible for perhaps a third of the influence on whether someone has same-sex sex.

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By Tina Hesman Saey. October 20, at am. In a large study of more thanmen and women in the United States, United Kingdom and Sweden, researchers discovered four genetic variants that occur more often in people who indicated on questionnaires that they had had same-sex sexual partners. The other two influence sex partner choice for both men and women.

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The differential diagnosis of differences or disorders of sex development DSD belongs to the most complex fields in medicine. It requires a multidisciplinary team conducting a synoptic and complementary approach consisting of thorough clinical, hormonal and genetic workups. Ascertainment of the karyotpye defines one of the three major diagnostic DSD subclasses and is therefore the mandatory initial step.

But geneticists have had only a handful of underpowered studies to address a complex, fraught, and often stigmatized area of human behavior. Now, the largest-ever study of the genetics of sexual orientation has revealed four genetic variants strongly associated with what the researchers call nonheterosexual behavior. Some geneticists are hailing the findings as a cautious but significant step in understanding the role of genes in sexuality.


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